LE CŒUR Sophie

Démographe-Épidémiologiste, Directrice de recherche, INED.
Elle a été chercheur puis chercheur associé au Ceped

Courriel : lecoeur chez ined.fr

Champs de recherche : Infection à VIH, prévention, santé maternelle et infantile, Asie du Sud-Est, morbidité, mortalité, Adolescents, qualité de vie, coût-efficacité.

Zones géographiques étudiées : Asie et Océanie.

Publications

  • Le Cœur Sophie (2009) « Socio-demographic impact of ARV on the lives of HIV-infected patients in Thailand: the LIWA study » (communication orale), présenté à The 2008 Harvard School of Public Health China 5th HIV/AIDS Workshop, Hainan.
  • Le Cœur Sophie (2010) « LIWA Results: Intergenerational Relations in HIV affected families » (communication orale), présenté à Atelier Living with ARV (LIWA): Results, Teens with ARV (TEEWA): Plans, Chiang Mai.
  • Le Cœur Sophie (2014) « Adolescents thaïlandais: situations, besoins et aspiration » (communication orale), présenté à Convention nationale Sida, Paris.
  • Le Cœur Sophie (2009) « HIV/AIDS Treatment Strategies in Poor Resources Settings » (communication orale), présenté à The 2008 Harvard School of Public Health China 5th HIV/AIDS Workshop, Hainan.

  • Le Cœur Sophie, Bozon Michel, Lelièvre Éva, Sirijitraporn Preecha, Pipustanawong Narongdate, Cowatcharagul Worawut et Pattanapornpun Nopporn (2014) « Marital sex among people living with HIV receiving antiretroviral treatment in Northern Thailand », Culture Health & Sexuality, 16 (8), p. 898-915. DOI : 10.1080/13691058.2014.920047.
  • Le Cœur Sophie, Collins Intira, Pannetier Julie et Lelièvre Eva (2009) « Gender Disparities for Access to Antiretrovirals in Thailand » (communication orale), présenté à International workshop: The Impact of HIV/AIDS and its Treatment in South-east Asia, Chiang Mai.
  • Le Cœur Sophie, Collins Intira, Pannetier Julie et Lelièvre Éva (2009) « Gender and access to HIV testing and antiretroviral treatments in Thailand: Why do women have more and earlier access? », Social Science & Medicine, 69 (6), p. 846-853.
    Résumé : In the recent scale-up of antiretroviral treatment, gender differences in access to treatment have been reported. In Thailand, as the HIV epidemic became more generalised, there has been a shift from men being disproportionately affected to increased vulnerability of women. In 2007, the Living with Antiretrovirals (LIWA-ANRS 12141) study investigated the gender distribution of all adult patients receiving antiretroviral therapy (N = 513 patients) in four community hospitals in northern Thailand and factors influencing the disparities observed. From this retrospective life-event history survey, we found that proportionately more women (53%) were receiving antiretroviral therapy than men, an unexpected result for a country with a higher proportion of infections among men. They were more likely to initiate treatment within one year of diagnosis and were at a more advanced stage of the disease compared to women. This gender distribution is partly explained by the evolving dynamics of the HIV epidemic, initial prioritization of mothers for treatment and earlier access to HIV testing for women. These issues are also entangled with gender differences in the reasons and timing to HIV testing at the individual level. This study found that the majority of men underwent HIV testing for health reasons while the majority of women were tested following family events such as a spouse/child death or during pregnancy. Further qualitative research on gender specific barriers to HIV testing and care, such as perceived low risk of infection, poor access to medical care, lack of social support, actual or anticipated HIV/AIDS-related stigma would provide greater insight. In the meantime, urgent efforts are needed to increase access to voluntary counselling and testing inside and outside the family setting with targeted interventions for men.
    Mots-clés : Access to treatment, Adolescent Adult Aged Anti-Retroviral Agents, diagnosis, drug therapy, Early Diagnosis Female HIV Infections, Gender, Health inequalities, Health Services Accessibility, Health Status Disparities, Healthcare Disparities, HIV, HIV testing, Humans Interviews as Topic, Life Change Events, Life-event histories, Male, Middle Aged, psychology, Retrospective Studies, Sex Factors, statistics & numerical data, Thailand, therapeutic use Chi-Square Distribution, Women, Young Adult.
  • Le Cœur Sophie, Duracinsky Martin, Acquadro Catherine, Berzins Baiba, Herrmann Susan, Fournier Isabelle, Diouf Assane, Kohli Rewa et Chassany Olivier (2008) « Developement of a New Health-Related Quality Of Life Questionnaire Specific to HIV/AIDS – Proqol HIV Study. International Society For Pharmacoeconomics and Outcomes Research » (communication orale), présenté à 11th Annual European Congress, Athènes.

  • Le Cœur Sophie et Kanjanavanit Suparat (2009) « The Evolution of Prevention of Mother-to-Child Transmission: From Simple to More Complex Regimens », in From the Ground Up: Building Comprehensive HIV/AIDS Care Programs in Resource-Limited Settings, éd. par Richard Marlink et Sarah Teitelman, Washington, DC : Elizabeth Glaser Pediatric AIDS Foundation, p. 775-794. http://ftguonline.org/ftgu-232/index.php/ftgu/article/download/2010/4017.

  • Le Cœur Sophie, Khlat Myriam et Halembokaka Gaston (2008) « Increased HIV infection rate among violent deaths: a mortuary study in the Republic of Congo », AIDS, 22, p. 1675-6. DOI : 10.1097/QAD.0b013e32830a98bc.
    Résumé : There is no evidence about an association between violent deaths and HIV in Africa. We report the results of a study performed in Pointe-Noire, Congo, where post-mortem HIV serologies were performed among all deaths referred to the morgue. The HIV prevalence among violent deaths was 37%, significantly higher than 10% among accidental deaths, with an adjusted odds ratio of 6 (P = 0.03). Prevention of domestic violence and fight against stigmatization should be parts of HIV programs in Africa.
    Mots-clés : Accidents/mortality, Adult, Cause of Death, CONGO, Domestic Violence, Female, HIV Infections/ mortality, Homicide, Humans, Logistic Models, Male, Prevalence, Suicide.
  • Le Cœur Sophie et Lelièvre Eva (2008) « Intergenerational relationships of HIV-infected patients in the ARV era: the patients’ perspective in Northern Thailand » (communication orale), présenté à Conference on the Impact of HIV/AIDS on Older Persons. University of Michigan, Ann Harbour, Mi.
  • Le Cœur Sophie et Lelièvre Eva (2013) « Family situation and living arrangement of HIV infected adolescents in Thailand » (communication orale), présenté à XXVII IUSSP International Population Conference, Busan, Korea.
  • Le Cœur Sophie et Lelièvre Eva (2012) « Aspects méthodologiques et questions éthiques autour du recueil d’informations biographiques sur des adolescents nés avec le VIH en Thaïlande » (communication orale), présenté à Être fille ou garçon : regards croisés sur l’enfance et le genre au Nord et au Sud (Journées Pôle Suds INED / CEPED), Paris.
  • Le Cœur Sophie, Lelièvre Eva et Collins Intira (2008) « Socio-demographic impact of antiretroviral treatments in Northern Thailand » (communication orale), présenté à Population Association of America Conference, Nouvelle Orléans (USA).
  • Le Cœur Sophie, Lelièvre Eva, Collins Intira et Kanabkaew Cheeraya (2012) « Enquête TEEWA (Teens with Antiretrovirals) sur la vie des adolescents nés avec le VIH en Thaïlande » (communication orale), présenté à 6ème Conférence Francophone sur le SIDA, Genève.
  • Le Cœur Sophie, Lelièvre Eva, Collins Intira et Kanabkaew Cheeraya (2012) « Assessing the lives of HIV-infected adolescents in Thailand: a coupled life-event history approach to adolescents and their caregivers. » (communication orale), présenté à The 2nd Asian Population Association Conference, Bangkok.

  • Le Cœur Sophie, Lelièvre Eva, Collins Intira et Pannetier Julie (2011) « Différences hommes-femmes dans le dépistage et le traitement du VIH en Thaïlande du Nord, dans un contexte d’accès quasi généralisé au test et aux antirétroviraux », in Les femmes à l'épreuve du VIH dans les pays du Sud : genre et accès universel à la prise en charge, éd. par Alice Desclaux, Philippe Msellati, et Khoudia Sow, Paris : ANRS, p. 55-69. (Sciences Sociales et Sida). http://www.anrs.fr/Ressources-et-publications/Publications/Publications-ANRS/Les-femmes-a-l-epreuve-du-VIH-dans-les-pays-du-Sud.-Genre-et-acces-universel-a-la-prise-en-charge.
  • Le Cœur Sophie, Lelièvre Eva et Kanabkaew Cheeraya (2013) « HIV disclosure: the situation of adolescents born with HIV in Thailand [AIDS Impact] » (communication orale), présenté à XI International AIDS Impact Conference, Barcelona.
  • Le Cœur Sophie, Lelièvre Eva, Kanabkaew Cheeraya, Suwunta Surush, Jongpaijitsakol Parinya et Collins Intira (2011) « Teens living with HIV in Thailand (TEEWA) » (communication orale), présenté à Annual conference of the Society for Applied Anthropology, Seattle.
  • Le Cœur Sophie, Lelièvre Eva, Kanabkaew Cheeraya, Techakunakorn Pornchai, Ngampiyasakul Chaiwat, Wanchaitanawong Vanichaya, Buranabanjasatean Sudanee, Karnchanamayul Varut, Nitipipatkosol J, Warachit V et Akarathum Noppadon (2013) « HIV disclosure: the situation of adolescents born with HIV in Thailand » (communication orale), présenté à 7th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2013), Kuala Lumpur.
  • Le Cœur Sophie (2011) « Sida », éd. par France Meslé, Laurent Toulemon, et Jacques Véron, Dictionnaire de démographie et des sciences de la population, Armand Colin.
  • Le Cœur Sophie (2011) « Santé », éd. par France Meslé, Laurent Toulemon, et Jacques Véron, Dictionnaire de la démographie, Armand Colin.
  • Le Cœur Sophie, Pannetier Julie, Cowatcharagul Worawut, Pattanapornpun Nopporn, Sirijitraporn Preecha, Pipustanawong Narongdate et Kanabkaew Cheeraya (2011) « Prevention de la transmission mère-enfant (PTME) : un point d'entrée pour le dépistage et le traitement chez les femmes, les hommes et les enfants nés de mères infectées par le VIH en Thailande du Nord. Recherches en prévention sur la transmission mère-enfant du VIH dans les pays du Sud : l'apport des sciences sociales » (communication orale), présenté à Atelier thematique du Groupe Mère enfant de l'AC12, ANRS, Paris.
  • Le Cœur Sophie, Pannetier Julie, Cowatcharagul Worawut, Pattanapornpun Nopporn, Sirijitraporn Preecha, Pipustanawong Narongdate et Kanabkaew Cheeraya (2011) « Prevention of mother to child transmission of HIV (PMTCT): an entry point to HIV testing and ARV treatment among women, men and children born to HIV-infected mothers in Northern Thailand » (poster), présenté à 13th National AIDS Seminar entitle "AIDS Rights is Human Rights, Join to Protect and Respond", Nonthaburi.

  • Lelièvre Eva et Le Cœur Sophie (2012) « Intergenerational relationships within families of HIV-infected adults under antiretroviral treatment in Northern Thailand. », Ageing and Society, 32 (4), p. 561-585. DOI : 10.1017/S0144686X11000389.
  • Lelièvre Eva et Le Cœur Sophie (2009) « Intergenerational relationships of HIV-infected patients under antiretroviral treatment: Patients’ perspective in Thailand » (communication orale), présenté à The Impact of HIV/AIDS and its Treatment in South-East Asia, International workshop, Chiang Mai.
  • Lelièvre Eva et Le Cœur Sophie (2010) « Vieillir avec le VIH : les relations intergénérationnelles en Thaïlande dans un contexte d’accès généralisé aux traitements », Autrepart, 53, p. 149-168.

  • Lelièvre Eva et Le Cœur Sophie (2010) « Relations intergénérationnelles dans un contexte d’accès généralisé au traitement du sida en Thaïlande: parents âgés, enfants adultes », Autrepart, 53, p. 149-168. http://www.cairn.info/resume.php?ID_ARTICLE=AUTR_053_0147.
  • Maynart Maryvonne, Leurent Baptiste, Jourdain Gonzague, Luekamlung Nuananong, Wittayapraparat Pakorn, Le Cœur Sophie, Yuthavisuthi Prapap, Achalapong Jullapong, Chotivanich Nantasak, Lallemant Marc et Program for HIV Prevention and Treatment (PHPT) (2008) « Cervical intraepithelial neoplasia in HIV-infected women on antiretroviral therapy (PHPT cohort) in Thailand » (poster A-072-0076-12614), présenté à XVII International AIDS Conference, Mexique.
  • Nammuang Supaluck, Punyasriwichai Sompol, Charauonwong Sariwanee, Saimee Atjaree, Chalermpantmetagul Suwalai, Kanabkaew Cheeraya, Sukrakanchana Praornsuda, Le Cœur Sophie et Jourdain Gonzague (2013) « Community advisory board for HIV and infectious disease research: experience from PHPT, Thailand », présenté à 11th International Congress on AIDS in Asia and the Pacific, Bangkok.

  • Ngo-Giang-Huong Nicole, Decker Luc, Sirirungsi Wasna, Le Cœur Sophie, Jourdain Gonzague, Khamduang Woottichai, Kanjanavanit Suparat, Matanasarawut Wanmanee, Putiyanun Chaiwat, Barin Francis et Lallemant Marc (2009) « Risk factors for HCV infection in HIV positive pregnant women and rate of HCV perinatal transmission in Thailand » (communication orale), présenté à 5th Dominique Dormont International Conference. Mother-to-child transmitted viral diseases: from transmission to children care, Paris. DOI : 10.1186/1742-4690-6-S1-O15.

  • Ngo-Giang-Huong Nicole, Jourdain Gonzague, Sirirungsi Wasna, Decker Luc, Khamduang Woottichai, Le Cœur Sophie, Sirinontakan Surat, Somsamai Rosalin, Pagdi Karin, Hemvuttiphan Jittapol, McIntosh Kenneth, Barin Francis et Lallemant Marc (2010) « Human immunodeficiency virus-hepatitis C virus co-infection in pregnant women and perinatal transmission to infants in Thailand », Int J Infect Dis, 14, p. e602-7. DOI : 10.1016/j.ijid.2009.09.002.
    Résumé : OBJECTIVES: The objectives of this study were to assess the prevalence and factors associated with hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-infected and -uninfected Thai pregnant women and the rate of HCV transmission to their infants. PATIENTS AND METHODS: Study subjects included 1435 HIV-infected pregnant women and their infants, enrolled in a perinatal HIV prevention trial, and a control group of 448 HIV-uninfected pregnant women. Women were screened for HCV antibodies with an enzyme immunoassay. Positive results were confirmed by recombinant immunoblot and HCV RNA quantification. Infants were tested for HCV antibodies at 18 months or for HCV RNA at between 6 weeks and 6 months. RESULTS: Of the HIV-infected women, 2.9% were HCV-infected compared to 0.5% of HIV-uninfected women (p=0.001). Only history of intravenous drug use was associated with HCV infection in HIV-infected women. Ten percent of infants born to co-infected mothers acquired HCV. The risk of transmission was associated with a high maternal HCV RNA (p=0.012), but not with HIV-1 load or CD4 count. CONCLUSIONS: Acquisition of HCV through intravenous drug use partially explains the higher rate of HCV infection in HIV-infected Thai women than in HIV-uninfected controls. Perinatal transmission occurred in 10% of infants of HIV-HCV-co-infected mothers and was associated with high maternal HCV RNA.
    Mots-clés : Adult, Anti-HIV Agents/administration & dosage, CD4 Lymphocyte Count, complications/prevention & control/transmission/virology, epidemiology Viral Load, Female HIV Infections, Hepacivirus/genetics/isolation & purification, Hepatitis C Antibodies/blood, Hepatitis C/ complications/ transmission/virology, HIV-1/genetics/isolation & purification, Humans Infant, Newborn Infectious Disease Transmission, Vertical Pregnancy, Pregnancy Complications, Infectious/epidemiology, Risk Factors Substance Abuse, Intravenous/ complications/epidemiology, Thailand, virology Prevalence RNA, Viral/blood Reverse Transcriptase Inhibitors/administration & dosage, Young Adult, Zidovudine/administration & dosage.
  • Pannetier Julie, Le Cœur Sophie, Collins Intira et Lelièvre Eva (2009) « From HIV counselling & testing to antiretroviral treatment: An assessment of gender differences in Northern Thailand » (communication orale), présenté à XXVI international population conference of the International Union of IUSSP, Marrakech.


  • Pannetier Julie, Lelièvre Eva et Le Cœur Sophie (2015) « HIV-related stigma experiences: Understanding gender disparities in Thailand », AIDS care (octobre 19), p. 1‑9. DOI : 10.1080/09540121.2015.1096888. http://www.tandfonline.com/doi/abs/10.1080/09540121.2015.1096888?journalCode=caic20.
    Résumé : This paper assesses the relationship between gender and HIV-related stigma experiences among people living with HIV (PLHIV) - enacted and anticipated stigma - and PLHIV caregivers - courtesy stigma - in Northern Thailand, along with the underlying reasons for stigmatising attitudes towards PLHIV - instrumental and symbolic stigma - expressed in the general population. We used data from the Living With Antiretrovirals (LIWA) study conducted on all PLHIV receiving antiretroviral treatment in four district hospitals in Northern Thailand (n = 513) and on a community sample of adults from the general population (n = 500). Women living with HIV and female caregivers of PLHIV reported higher rates of HIV-related stigma experiences than men. Gender interacted with other predictors - the period of HIV diagnosis and age - to increase the level of stigma experienced. Among the general population, attitudes of contact avoidance were infrequent. However, stereotypes depicting PLHIV as blameworthy were highly pervasive, with women perceived as the "victims" of their spouse's irresponsible sexual behaviours. In this context, women were yet more often subjected to HIV-related stigma than men, in particular women diagnosed in the pre-antiretroviral therapy era and younger female caregivers. The role of gender in shaping disparities in HIV-related stigma experiences is discussed.
    Mots-clés : Care, Genre, stigmatisation, Thaila, VIH.
  • Pornprasert Sakorn, Mary Jean-Yves, Faye Albert, Leechanachai Pranee, Limtrakul Aram, Rugpao Sungwal, Sirivatanapa Pannee, Gomuthbutra Vorapin, Matanasarawut Wanmanee, Le Cœur Sophie, Lallemant Marc, Barre-Sinoussi Françoise, Menu Elisabeth et Ngo-Giang-Huong Nicole (2009) « Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine », Curr HIV Res, 7, p. 211-7.
    Résumé : Placental cytokine balance may be critical for the control of mother-to-child transmission (MTCT) of HIV. We assessed whether the type and duration of antiretrovirals used for prevention of HIV-1-MTCT modified the inflammatory cytokine profile. We investigated the levels of cytokine expression in the placentas of 61 HIV-1-infected women who received zidovudine (ZDV) plus single dose nevirapine (SD-NVP) or ZDV only for prevention of MTCT. Placentas of 38 HIV-1-uninfected women were included as controls. All placentas were obtained after vaginal delivery. Levels of mRNA and cytokine expression were quantified using real-time PCR and ELISA, respectively, in placental explants and 24-hour culture supernatants and analyzed in relation to the women's characteristics and the type and duration of antiretroviral prophylaxis. HIV-1-infected and uninfected women did not show any differences in the expression of placental cytokine secretion except for a trend toward lower TNF-alpha mRNA levels in HIV-1-infected women. Within the HIV-1-infected group, women who were exposed to a long duration of ZDV (>72 days) or received SD-NVP less than 5h prior to delivery, more frequently expressed detectable levels of IL-10 in their placentas (32% versus 7% (p = 0.01) and 32% versus 5% (p = 0.02), respectively). No infant was found to be HIV-1-infected. Our results showed a normalization of the placental cytokine balance in HIV-1-infected women receiving antiretroviral prophylaxis. Furthermore, the type and duration of antiretroviral prophylaxis have an impact on the placental anti-inflammatory IL-10 expression level, which may contribute to controlling HIV replication at the placental level, thus reducing MTCT of HIV-1.
    Mots-clés : Adult, Anti-HIV Agents/ therapeutic use, Female, HIV Infections/drug therapy/ immunology/virology, HIV-1/ immunology, Humans, Interleukin-10/ biosynthesis, Nevirapine/ therapeutic use, Placenta/ immunology, pregnancy, Pregnancy Complications, Infectious/drug therapy/ immunology, Time Factors, Young Adult, Zidovudine/ therapeutic use.
  • Sirirungsi Wasna, Samleerat Tanawan, Ngo-Giang-Huong Nicole, Collins Intira, Khamduang Woottichai, Caritey Benoît-Damien, Le Cœur Sophie, Pusamang Artit et Leechanachai Pranee (2013) « Thailand National Program for Early Infant HIV Diagnosis : Six-year Experience using Real-time DNA PCR on Dried Blood Spots » (communication orale), présenté à 5th International workshop on HIV Pediatrics, Kuala Lumpur.

  • Sirirungsi Wasna, Urien Saik, Harrison Lida, Kamkon Jiraporn, Tawon Yardpiroon, Luekamlung Nuananong, Thongpaen Suchart, Nilmanat Ampaipith, Jourdain Gonzague, Lallemant Marc, Le Cœur Sophie, Ngo-Giang-Huong Nicole, Owen Andrew et Cressey Tim R. (2015) « No relationship between drug transporter genetic variants and tenofovir plasma concentrations or changes in glomerular filtration rate in HIV-infected adults », J Acquir Immune Defic Syndr., 68 (4) (avril 1). DOI : 10.1097/QAI.0000000000000504.
  • Sripan Patumrat, Le Cœur Sophie, Ingsrisawang Lily, Cressey Tim R., Tréluyer Jean-Marc, Bouazza Naïm, Foissac Frantz, Jourdain Gonzague, Lallemant Marc et Urien Saïk (2015) « Specific Effects of ZDV, 3TC and LPV/r on HIV-1 RNA Viral Load during Pregnancy » (communication orale), présenté à Conference on Retroviruses and Opportunistic Infections (CROI), Seattle.
  • Thawsirichuchai R., Chataw Lakela, Yangyernkun Wirachon, Kunstadter Peter, Lallemant Marc, Le Cœur Sophie, Kanabkaew Cheeraya, Chalermpantmetagul Suwalai et Lazarus Margery (2011) « Access to, delivery of, and effective use of HIV-related services in Northern Thailand » (communication orale), présenté à Annual conference of the Society for Applied Anthropology, Seattle.
  • Traisathit Patrinee, Homkham Nontiya, Chalermpantmetagul Suwalai, Na-Rajsima Sathaporn, Bunjongpak Suthunya, Attavinijtrakarn Pornsawan, Hanpinitsak, Puangsombat S., Barbier Sylvaine, Lallemant Marc, Jourdain Gonzague et Le Cœur Sophie (2010) « Tuberculosis and risk of death within one year of antiretroviral therapy initiation in children » (poster), présenté à 28th Annual Meetings of The European Society for Paediatric Infectious Diseases, Nice.
  • Traisathit Patrinee, Jourdain Gonzague, Le Cœur Sophie, Briand Nelly, Lechenadec Jerôme, Mekmullica Jutarat, Techakunakorn Pornchai, Kosonsasitorn Rujeerat, Lertpienthum Narong, Puangsombat Achara et Lallemant Marc (2009) « Effect of antiretroviral therapy on the growth of HIV infected children in Thailand » (poster 13-302), présenté à 13th International Workshop on HIV Observational Databases, Lisbonne.
  • Traisathit Patrinee, Jourdain Gonzague, Le Cœur Sophie, Briand Nelly, Lechenadec Jerôme, Mekmullica Jutarat, Techakunakorn Pornchai, Kosonsasitorn Rujeerat, Lertpienthum Narong, Puangsombat Achara, Wanchaitanawong Vanichaya, Kwanchaipanich Ratchanee, Nantarukchaikul Maneeratn, Santadusit Sadhit et Lallemant Marc (2009) « Growth of HIV infected children on antiretroviral therapy in Thailand: 2 years follow-up » (poster P40), présenté à 1st International Workshop on HIV Pediatrics, Cape Town (Afrique du Sud).
  • Traisathit Patrinee, Mary Jean-Yves, Le Cœur Sophie, Thantanarat Sudanee, Jungpichanvanich Sivaporn, Pornkitprasarn Witaya, Gomuthbutra Vorapin, Matanasarawut Wanmanee, Wannapira Wiroj et Lallemant Marc (2009) « Risk factors of preterm delivery in HIV-infected pregnant women receiving zidovudine for the prevention of perinatal HIV », J Obstet Gynaecol Res, 35, p. 225-33.
    Résumé : AIM: Several studies have shown that preterm delivery, a primary cause of perinatal mortality and morbidity, is more frequent in HIV-positive women. This study aimed to determine factors associated with prematurity in HIV-infected women and identify risks for which specific interventions could be targeted. METHODS: Data were prospectively collected in a clinical trial assessing the efficacy of different zidovudine prophylaxis durations for the prevention of perinatal HIV transmission in Thailand. Characteristics associated with prematurity - delivery before 37 weeks--were assessed using univariate and multivariate logistic regression and were subsequently used to identify subgroups of women at risk. RESULTS: Among 979 women, independent prematurity risk factors were: viral load <3.5 or >4.5 log copies/mL; hemoglobin > 11.5 g/dL; weight gain <0.25 kg/week; and body mass index <20 kg/m2. These factors allowed us to define four subgroups with an expected probability of prematurity increasing from 3% to 30%. The two subgroups with the highest expected probability of prematurity were considered to be 'at risk' as opposed to the two lowest (odds ratio = 2.6, 95% confidence interval: 1.7-4.0) and the sensitivity and specificity of the prediction were 51% and 71%, respectively. CONCLUSION: In this study, four risk factors of preterm delivery were identified allowing the identification of subgroups at increasing risk of prematurity. Adequate nutrition and the provision of highly active antiretroviral therapy during pregnancy as recommended by the World Health Organization for the prevention of perinatal transmission for immunocompromised women in resource-constrained countries may reduce the risk of premature delivery.
    Mots-clés : Adult, Anti-HIV Agents, drug therapy Risk Factors, drug therapy/prevention & control, etiology Pregnancy, Female HIV Infections, Highly Active CD4, Humans Infant, Newborn Infectious Disease Transmission, Vertical, Lymphocyte Count, Pregnancy Complications, Infectious, Premature, prevention & control Obstetric Labor, therapeutic use Antiretroviral Therapy, Viral Load, Zidovudine/ therapeutic use.
  • Ya-a-nan Prangtip, Saengkham Sirinthip, Taboon Chureeporn, Sanyabhumi Yuppakarn, Satthathaweekun Somruethai, Chamnong Kasemsri, Chalermpantmetagul Suwalai et Le Cœur Sophie (2013) « Youth Community Advisory Board (Youth-CAB) for HIV research: experiences from PHPT research unit » (communication orale), présenté à 11th International Congress on AIDS in Asia and the Pacific, Bangkok.
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