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2019

Intérêt du test HPV dans le dépistage primaire du cancer du col en milieu rural à Madagascar

Dumont Alexandre, Bessières N., Razafindrafara G., Ravit Marion, Benbassa André



Dumont Alexandre, Bessières N., Razafindrafara G., Ravit Marion et Benbassa André (2019) « Intérêt du test HPV dans le dépistage primaire du cancer du col en milieu rural à Madagascar », Revue d'Épidémiologie et de Santé Publique, 67 (2) (avril), p. 120-125. DOI : 10/gf3jjz. https://linkinghub.elsevier.com/retrieve/pii/S0398762018313622.
itemfields keyQCMBTN4P
Version12599
TypeArticle de revue
TitreIntérêt du test HPV dans le dépistage primaire du cancer du col en milieu rural à Madagascar
AuteurDumont, Alexandre
AuteurBessières, N.
AuteurRazafindrafara, G.
AuteurRavit, Marion
AuteurBenbassa, André
RésuméBackground. - Testing for high-risk human papilloma virus (HR-HPV) is an effective approach to the prevention of cervical cancer. This study in the Atsinanana area of Madagascar aimed to compare the management of women screened by visual inspection after coloration with acetic acid (VIA) and the management of women screened by HPV with VIA as a triage test. Method. - During the last two screening campaigns, the first patients (between 28 and 120 women par center) were sampled using a dry swab, just before the acetic acid application, to test 14 genotypes of HR-HPV using Roche Diagnostics Cobas (R) Test. We compared current management practices based on primary VIA to those that would have been implemented if the clinician had followed the recommendations of the World Health Organization for HPV-based primary screening. We used a regression Poisson model with random effect and robust variance. Results. - Among the 250 screened-women, 28 (11.2%) had acidophilic lesions of the uterine cervix or suspected lesions of invasive cancer (IVA +). The HPV test was positive in 62 cases (24.8%). The HPV-based screening strategy would have reduced by 52% the number of women needing thermocoagulation treatment: 24 women (9.6%) with primary VIA-based screening vs. 13 women (5.2%) with primary HPV-based screening; RR: 0.52 and 95%CI: 0.27-1.02. The diagnosis of severe dysplastic lesion or invasive cancer would not have changed. Conclusion. - Primary HPV-based screening is a strategy that could be useful for low-resource countries like Madagascar. It would reduce the rate of false positives and unnecessary treatments compared to the current strategy based on primary IVA. The questions of the feasibility and cost-benefit of this strategy should be further explored.
PublicationRevue d'Épidémiologie et de Santé Publique
Volume67
Numéro2
Pages120-125
Date2019-04
Languefr
DOI10/gf3jjz
ISSN03987620
URLhttps://linkinghub.elsevier.com/retrieve/pii/S0398762018313622
Consulté le2019-05-21T18:15:03Z
Catalogue de bibl.Crossref
ExtraWOS:000462038500006
Date d'ajout2019-05-21T18:15:03Z
Modifié le2019-06-04T13:55:45Z