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Kouassi Arsene Kra, Fotso Arlette Simo, Rouveau Nicolas, Maheu-Giroux Mathieu, Boily Marie-Claude, Silhol Romain, d’Elbée Marc, Vautier Anthony et Larmarange Joseph (2023) « Estimating HIV self-testing positivity rate and linkage to confirmatory testing and care: a telephone survey in Côte d’Ivoire, Mali and Senegal » (communication orale), présenté à AIDS Impact Conference, Stockholm. https://hal.science/hal-04120705.

Résumé : Background HIV self-testing (HIVST) empowers individuals and allow them to decide when/where to test and with whom to share their result. Between 2019 and 2022, the ATLAS program distributed 400 000 HIVST kits in a mixed epidemic context (Côte d’Ivoire, Mali and Senegal), prioritizing key populations, including female sex workers (FSW) and men who have sex with men (MSM), and encouraged secondary distribution of HIVST to their partners, peers and FSW clients. To preserve its confidential nature, distributed HIVST kits were not systematically tracked. An anonymous phone survey was implemented among its users to estimate test positivity rates and linkage to confirmatory testing and care. Methods We conducted a two-step survey. Between March and June 2021, participants were recruited using dedicated leaflets distributed with HIVST kits, inviting users to call a free phone number anonymously (participation was rewarded USD $3.40) and to complete a sociobehavioural questionnaire (phase 1), including the self-reported number of visible lines on their HIVST kits and their interpretation of results. In September and October 2021, participants who reported a reactive HIVST result in phase 1 and agreed to be re-contacted were recalled to complete a short questionnaire (phase 2) on linkage to confirmatory testing and care. Results During phase 1, 2 615 participants were recruited: 2 346 (89.7%) reported a consistent HIVST result (2 visible lines and result interpreted as reactive; one line and interpreted as non-reactive; or no/one line and interpreted as invalid), 48 (1.8%) reported an inconsistent result and 221 (8.5%) did not know (DK) how to interpret their result or refused to answer. HIVST positivity rates ranged from 2.4% to 4.5%, depending on different assumptions (self-interpreted result or reported number of lines, inclusion or exclusion of DK and refusals). Among men who received an HIVST through activities targeting MSM, positivity rates ranged from 3.2% to 4.8%, and from 2.2% to 4.2% for women reached through activities targeting FSW. Among 126 phase 1 participants eligible for phase 2, 120 agreed to be re-contacted, and 78 fully completed the phase 2 questionnaire. Among the 27 who reported a consistent reactive result in the phase 1 questionnaire, 15 (56%, 95%CI: 36-74%) linked to confirmatory test, including 12 (80%) confirmed HIV-positive, which all started treatment (100%). Linkage was lower among those who reported an inconsistent result in phase 1(37%, 95%CI: 24-52%). Among those confirming reactive self-tests, 53% did it in less than one week following self-testing, and 91% in less than three months. Two-thirds (65%) went to a general public facility and one-third to a facility dedicated to key populations. Conclusion Our HIVST distribution strategy successfully reached people living with HIV in West Africa. Linkage to confirmatory testing remained sub-optimal in these first years of HIVST implementation. However, if confirmed HIV-positive, almost all initiated treatment. The majority of those who linked to confirmatory testing went to a general facility, suggesting that HIVST has the potential to reach more discrete populations. HIVST constitutes a complementary tool to existing screening services.

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Kouassi Kra Djuhe Arsene, Fotso Arlette Simo, Rouveau Nicolas, Maheu-Giroux Mathieu, Boily Marie-Claude, Silhol Romain, d'Elbee Marc, Vautier Anthony et Larmarange Joseph (2023) « HIV self-testing positivity rate and linkage to confirmatory testing and care: a telephone survey in Côte d'Ivoire, Mali and Senegal ». https://hal.science/hal-04127016.

Résumé : HIV self-testing (HIVST) empowers individuals by allowing them to decide when and where to test and with whom to share their results. From 2019 to 2022, the ATLAS program distributed ≈ 400 000 HIVST kits in Côte d Ivoire, Mali, and Senegal. It prioritised key populations, including female sex workers and men who have sex with men, and encouraged secondary distribution of HIVST to their partners, peers and clients. To preserve the confidential nature of HIVST, use of kits and HIVST results were not systematically tracked. Therefore, an anonymous phone survey was conducted to estimate HIVST positivity rates and linkage to confirmatory testing and care. This two-step survey involved an initial recruitment phase from March to June 2021 where participants were encouraged via leaflets to call a free phone number and complete a sociobehavioural questionnaire. This was followed by a second phase in September and October 2021, where participants who reported a reactive HIVST result were re-contacted to complete a further questionnaire. Of the 2 615 participants recruited during the first phase, 89.7% reported consistent results (2 visible lines and result interpreted as reactive; one line and interpreted as non-reactive; or no/one line and interpreted as invalid). HIVST positivity rates varied between 2.4% to 9.1% based on calculation methods (i.e. self-interpreted result or reported number of lines, inclusion or exclusion of don t knows and refusals). The second phase saw 78 out of 126 eligible participants complete the questionnaire. Of the 27 who reported a consistent reactive result in the first phase, 15 (56%, 95%CI: 36 to 74%) underwent confirmatory HIV testing, with 12 (80%) confirmed as HIV-positive, all of whom began antiretroviral treatment. The confirmation rate of HIVST results was fast, with 53% doing so within a week and 91% within three months of self-testing. Two-thirds (65%) went to a general public facility, and one-third to a facility dedicated to key populations. The ATLAS HIVST distribution strategy reached people living with HIV in West Africa. Linkage to confirmatory testing remained sub-optimal in these first years of HIVST implementation. However, if confirmed HIV-positive, almost all initiated treatment. HIVST constitutes a relevant complementary tool to existing screening services.

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Kra Arsène Kouassi, Fosto Arlette Simo, N’guessan Kouassi Noël, Geoffroy Olivier, Younoussa Sidibé, Kabemba Odé Kanku, Gueye Papa Alioune, Ndeye Pauline Dama, Rouveau Nicolas, Boily Marie-Claude, Silhol Romain, d’Elbée Marc, Maheu-Giroux Mathieu, Vautier Anthony, Larmarange Joseph et on behalf of the ATLAS team (2023) « Can HIV self-testing reach first-time testers? A telephone survey among self-test end users in Côte d’Ivoire, Mali, and Senegal », BMC Infectious Diseases, 22 (1) (septembre 25), p. 972. DOI : 10.1186/s12879-023-08626-w. https://doi.org/10.1186/s12879-023-08626-w.

Résumé : Coverage of HIV testing remains sub-optimal in West Africa. Between 2019 and 2022, the ATLAS program distributed ~400 000 oral HIV self-tests (HIVST) in Côte d’Ivoire, Mali, and Senegal, prioritising female sex workers (FSW) and men having sex with men (MSM), and relying on secondary redistribution of HIVST to partners, peers and clients to reach individuals not tested through conventional testing. This study assesses the proportion of first-time testers among HIVST users and the associated factors.

Mots-clés : Côte d’Ivoire, HIV self-testing, Key populations, Mali, Phone‐based survey, Senegal, West Africa.

Kra et al_2023_Can HIV self-testing reach first-time testers.pdf 1.8 Mio (source)

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Ky-Zerbo Odette, Desclaux Alice, Boye Sokhna, Maheu-Giroux Mathieu, Rouveau Nicolas, Vautier Anthony, Camara Cheick Sidi, Kouadio Brou Alexis, Sow Souleymane, Doumenc-Aidara Clémence, Gueye Papa Alioune, Geoffroy Olivier, Kamemba Odé Kanku, Ehui Eboi, Ndour Cheick Tidiane, Keita Abdelaye, Larmarange Joseph et for the ATLAS team (2023) « “I take it and give it to my partners who will give it to their partners”: Secondary distribution of HIV self-tests by key populations in Côte d’Ivoire, Mali, and Senegal », BMC Infectious Diseases, 22 (1) (mai 24), p. 970. DOI : 10.1186/s12879-023-08319-4. https://doi.org/10.1186/s12879-023-08319-4.

Résumé : HIV epidemics in Western and Central Africa (WCA) remain concentrated among key populations, who are often unaware of their status. HIV self-testing (HIVST) and its secondary distribution among key populations, and their partners and relatives, could reduce gaps in diagnosis coverage.

Mots-clés : ATLAS, HIVST, Key population, Secondary distribution, West and Central Africa.

Ky-Zerbo et al_2023_“I take it and give it to my partners who will give it to their partners”.pdf 1.2 Mio (source)

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Silhol Romain, Maheu-Giroux Mathieu, Soni Nirali, Fotso Arlette Simo, Rouveau Nicolas, Vautier Anthony, Doumenc-Aidara Clemence, Geoffroy Olivier, N'Guessan Kouassi Noel, Sidibe Younoussa, Kabemba Ode Kanku, Gueye Papa Alioune, Mukandavire Christinah, Vickerman Peter, Keita Abdelaye, Ndour Cheikh Tidiane, Ehui Eboi, Larmarange Joseph, Boily Marie-Claude et Team The ATLAS (2023) « Assessing the potential population-level impacts of HIV self-testing distribution among key populations in Cote d'Ivoire, Mali, and Senegal: a mathematical modelling analysis », medRxiv. DOI : 10.1101/2023.08.23.23294498. https://www.medrxiv.org/content/10.1101/2023.08.23.23294498v2.

Résumé : Background: A third of people living with HIV (PLHIV) in Western Africa had an undiagnosed infection in 2020. In 2019-2021, the ATLAS programme has distributed a total of 380 000 HIV self-testing (HIVST) kits to key populations (KP) including female sex workers (FSW) and men who have sex with men (MSM), and their partners in Cote d'Ivoire, Mali and Senegal. We predicted the potential impact of ATLAS and of national HIVST scale-up strategies among KP. Methods: A deterministic model of HIV transmission was calibrated to country-specific empirical HIV and intervention data over time. We simulated scenarios reflecting 1) the actual ATLAS HIVST distribution only over 2019-2021 (~2% of all tests done in countries), and 2) ATLAS followed by a scale-up of HIVST distribution to KP (total of ~570 000 kits distributed each year). Impacts on HIV diagnosis, new HIV infections and deaths were derived using counterfactual scenarios without HIVST. Findings: ATLAS was predicted to substantially increase HIV diagnosis among KP by the end of 2021, especially among MSM in Mali (94.3 percentage point [pp] increase), and a 1.0pp increase overall. ATLAS might have averted a median of 706 new HIV infections among KP over 2019-2028 in the 3 countries combined, especially among MSM, and 1794 new HIV infections (0.4-3.3% of all new HIV infections across countries) and 591 HIV-related deaths overall. HIVST scale-up increased HIV diagnosis at the end of 2028 by around 8pp among FSW and 33pp among MSM in every country. Overall increases ranged from 1.0pp (Cote d'Ivoire) to 11.0pp (Senegal). HIVST scale-up may avert 3-5% of new HIV infections among FSW, 3-10% among FSW clients, and 20-28% among MSM across countries (and 2-16% overall), and avert 13-18% of HIV-related deaths among MSM over 2019-2028. Interpretation: Scaling-up HIVST distribution among KP in Western Africa may substantially attenuate disparities in access to HIV testing and help reduce HIV infections and deaths among KP and their partners.

Silhol et al_2023_Assessing the potential population-level impacts of HIV self-testing.pdf 200.6 kio (source)

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